Comments on: Pumping Insulin http://asweetlife.org/robert/blogs/insulin-pumps/pumping-insulin/2902/ the source for the healthy diabetic Sun, 14 Mar 2010 19:48:53 -0400 http://wordpress.org/?v=2.9.2 hourly 1 By: Robert http://asweetlife.org/robert/blogs/insulin-pumps/pumping-insulin/2902/comment-page-1/#comment-479 Robert Thu, 24 Dec 2009 03:57:27 +0000 http://asweetlife.org/?p=2902#comment-479 Hi Paul, The fast acting insulins are necessary for the pump to be able to supply useable insulin quickly and my guess is that they are still under patent. All of them are mutants of insulin (genetically engineered) and required a fair amount of work to design and test. They will go off patent eventually but since they are still fairly new that won't happen anytime soon. Hi Paul,
The fast acting insulins are necessary for the pump to be able to supply useable insulin quickly and my guess is that they are still under patent. All of them are mutants of insulin (genetically engineered) and required a fair amount of work to design and test. They will go off patent eventually but since they are still fairly new that won’t happen anytime soon.

]]> By: Paul Sorensen http://asweetlife.org/robert/blogs/insulin-pumps/pumping-insulin/2902/comment-page-1/#comment-475 Paul Sorensen Tue, 22 Dec 2009 23:27:44 +0000 http://asweetlife.org/?p=2902#comment-475 Robert My brother and I are both type 1.  We find it shocking that there hasn't been a <em>generic  </em>insulin option.  Does the genetic engineering aspect make this impossible?  Robert

My brother and I are both type 1.  We find it shocking that there hasn’t been a generic  insulin option.  Does the genetic engineering aspect make this impossible? 

]]> By: Robert http://asweetlife.org/robert/blogs/insulin-pumps/pumping-insulin/2902/comment-page-1/#comment-240 Robert Mon, 23 Nov 2009 20:46:38 +0000 http://asweetlife.org/?p=2902#comment-240 Great questions. My guess is that muscle movement will increase interstitial fluid movement via a sort of pumping action but it is only a guess. Humalog is already pretty quick (minutes) so it might be the case that simply breathing is enough to get interstitial fluid on its way. Your question about exercise is a bit tricky. I know that exercise improves insulin sensitivity. What I don't know is what the time course of improvement might be. Some people believe that exercise mobilizes older damaged fat molecules which have been actively inhibiting insulin receptor signal transduction. This probably takes at least an hour to manifest (a total guess!!). There are most likely other mechanisms at work as well but I do not know enough about them to comment right now. More immediately, exercise mobilizes GLUT4 glucose transporters via an insulin independent mechanism (involving the AMP kinase). In this sense exercise gets glucose out of the blood right away however it is not through insulin. Great questions. My guess is that muscle movement will increase interstitial fluid movement via a sort of pumping action but it is only a guess. Humalog is already pretty quick (minutes) so it might be the case that simply breathing is enough to get interstitial fluid on its way. Your question about exercise is a bit tricky. I know that exercise improves insulin sensitivity. What I don’t know is what the time course of improvement might be. Some people believe that exercise mobilizes older damaged fat molecules which have been actively inhibiting insulin receptor signal transduction. This probably takes at least an hour to manifest (a total guess!!). There are most likely other mechanisms at work as well but I do not know enough about them to comment right now. More immediately, exercise mobilizes GLUT4 glucose transporters via an insulin independent mechanism (involving the AMP kinase). In this sense exercise gets glucose out of the blood right away however it is not through insulin.

]]> By: Catherine Price http://asweetlife.org/robert/blogs/insulin-pumps/pumping-insulin/2902/comment-page-1/#comment-233 Catherine Price Mon, 23 Nov 2009 18:58:18 +0000 http://asweetlife.org/?p=2902#comment-233 Great post -- and it made me think of a question I've always wondered about: can you get rapid-acting insulin (like humalog) to act more quickly if you exercise the area of the body into which you inject it? (In the case you mentioned, doing crunches after giving yourself a shot in your stomach?) I do that myself when I feel like the insulin is not acting quickly enough, and it seems to work -- but is that true? Or is it that any form of exercise will help you make better use of the insulin on board? Great post — and it made me think of a question I’ve always wondered about: can you get rapid-acting insulin (like humalog) to act more quickly if you exercise the area of the body into which you inject it? (In the case you mentioned, doing crunches after giving yourself a shot in your stomach?) I do that myself when I feel like the insulin is not acting quickly enough, and it seems to work — but is that true? Or is it that any form of exercise will help you make better use of the insulin on board?

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