{"id":12731,"date":"2010-12-13T06:52:00","date_gmt":"2010-12-13T11:52:00","guid":{"rendered":"http:\/\/asweetlife.org\/?p=12731"},"modified":"2015-12-29T08:07:57","modified_gmt":"2015-12-29T13:07:57","slug":"sperm-producing-cells-turned-into-insulin-producers","status":"publish","type":"post","link":"https:\/\/asweetlife.org\/?p=12731","title":{"rendered":"Sperm-Producing Cells Turned Into Insulin Producers"},"content":{"rendered":"<p style=\"text-align: justify;\">Human spermatogonial stem cells extracted from testicular tissue can be turned into insulin-secreting beta islet cells normally found in the pancreas, say scientists from Georgetown University Medical Center (GUMC).<\/p>\n<p>The researchers, who presented yesterday at the American Society of Cell Biology&#8217;s 50th annual meeting in Philadelphia, took 1 gram of tissue from human testes which they retrieved from deceased human organ donors, and produced about one million stem cells in the laboratory. These cells showed many of the biological markers that characterize normal beta islet cells.\u00a0 The cells were then transplanted into the backs of immune deficient diabetic mice and were able to decrease glucose levels in those mice for about a week, demonstrating the cells were producing enough insulin to reduce hyperglycemia.<\/p>\n<div style=\"text-align: justify;\">While the effect lasted only week, the researchers say newer research has shown the yield can be substantially increased.<\/div>\n<p style=\"text-align: justify;\">The study\u2019s lead investigator, G. Ian Gallicano, Ph.D., says his strategy could provide a unique solution to treatment of individuals with type 1 diabetes (juvenile onset diabetes). Several novel therapies have been tried for these patients in the past, but each has drawbacks. Transplanting islet cells from deceased donors can result in rejection, plus few such donations are available. Researchers have also cured diabetes in mice using induced pluripotent stem (IPS) cells \u2013 adult stem cells that have been reprogrammed with other genes to behave like embryonic stem cells \u2013 but this technique can produce teratomas, or tumors, in transfected tissue, as well as problems stemming from the external genes used to create IPS cells, Gallicano says.<\/p>\n<p>The research was funded in part by the American Diabetes Association, patient contributions to the GUMC Office of Advancement, support from GUMC diabetes specialist <a href=\"http:\/\/explore.georgetown.edu\/people\/clements\/\" target=\"_blank\">Stephen Clement, M.D.,<\/a> and a grant from GUMC<\/p>\n<div style=\"text-align: justify;\">\n<p>Source: <a href=\"http:\/\/explore.georgetown.edu\/news\/?ID=54742&amp;PageTemplateID=295\" target=\"_blank\"><strong>Georgetown University Medical Center<\/strong><\/a><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Human spermatogonial stem cells extracted from testicular tissue can be turned into insulin-secreting beta islet cells normally found in the pancreas, say scientists from Georgetown University Medical Center (GUMC)&#8230;<\/p>\n","protected":false},"author":131,"featured_media":29417,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"","_relevanssi_noindex_reason":"","footnotes":""},"categories":[1445],"tags":[246,1499],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v22.9 (Yoast SEO v22.9) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Sperm-Producing Cells Turned Into Insulin 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