{"id":13372,"date":"2011-01-08T03:14:23","date_gmt":"2011-01-08T08:14:23","guid":{"rendered":"http:\/\/asweetlife.org\/?p=13372"},"modified":"2015-12-30T02:52:10","modified_gmt":"2015-12-30T07:52:10","slug":"new-type-2-diabetes-drug-kombiglyze-xr-now-available-across-the-us","status":"publish","type":"post","link":"https:\/\/asweetlife.org\/?p=13372","title":{"rendered":"New Type 2 Diabetes Drug Kombiglyze XR Now Available Across the US"},"content":{"rendered":"
\n
\"\"<\/a>Bristol-Myers Squibb Company and AstraZeneca announced that type 2 diabetes drug Kombiglyze XR (saxagliptin and metformin HCl extended-release), approved by the FDA<\/a>\u00a0on November 5, 2010, is now available by prescription in pharmacies across the United States. Kombiglyze XR is the first and only once-a-day metformin extended-release (XR) plus dipeptidyl peptidase-4 (DPP-4) inhibitor combination tablet offering strong glycemic control across hemoglobin A1c levels, fasting plasma glucose and post-prandial glucose.Kombiglyze XR is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes when treatment with both saxagliptin and metformin is appropriate. Kombiglyze XR should not be used for patients with type 1 diabetes or diabetic ketoacidosis and has not been studied in combination with insulin.<\/p>\n

Consistent with the Prescribing Information (PI) for metformin alone, the PI for Kombiglyze XR contains a boxed warning for lactic acidosis, a rare, but serious metabolic complication that can occur due to metformin accumulation during treatment with Kombiglyze XR.<\/p>\n

Once-a-day Kombiglyze XR combines saxagliptin (also known as ONGLYZA\u2122<\/sup>), a DPP-4 inhibitor, and metformin XR, a biguanide, in one tablet for the treatment of type 2 diabetes. Kombiglyze XR should generally be administered once a day with the evening meal, with gradual dose titration to reduce the gastrointestinal side effects associated with metformin. The maximum daily recommended dose is 5 mg for saxagliptin and 2,000 mg for metformin extended-release.<\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Bristol-Myers Squibb Company and AstraZeneca announced that type 2 diabetes drug Kombiglyze XR (saxagliptin and metformin HCl extended-release), approved by the FDA on November 5, 2010, is now available by prescription in pharmacies across the United States. Kombiglyze XR is the first and only once-a-day metformin extended-release (XR) plus dipeptidyl peptidase-4 (DPP-4) inhibitor combination tablet offering strong glycemic…<\/p>\n","protected":false},"author":131,"featured_media":29415,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"","_relevanssi_noindex_reason":"","footnotes":""},"categories":[1442],"tags":[1026,261,685],"yoast_head":"\nNew Type 2 Diabetes Drug Kombiglyze XR Now Available Across the US<\/title>\n<meta name=\"description\" content=\"Bristol-Myers Squibb Company and AstraZeneca announced that type 2 diabetes drug 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