{"id":17118,"date":"2011-06-16T13:18:03","date_gmt":"2011-06-16T17:18:03","guid":{"rendered":"http:\/\/asweetlife.org\/?p=17118"},"modified":"2015-12-28T07:29:31","modified_gmt":"2015-12-28T12:29:31","slug":"long-term-use-of-diabetes-drug-actos-may-increase-risk-of-cancer","status":"publish","type":"post","link":"https:\/\/asweetlife.org\/?p=17118","title":{"rendered":"Long Term Use of Diabetes Drug Actos May Increase Risk of Cancer"},"content":{"rendered":"

\"\"<\/a>The U.S. Food and Drug Administration (FDA) issued a safety announcement informing the public that use of the type 2 diabetes medication Actos (pioglitazone) for more than one year may be associated with an increased risk of bladder cancer. Information about this risk will be added to the Warnings and Precautions<\/em> section of the label for pioglitazone-containing medicines. The patient Medication Guide for these medicines will also be revised to include information on the risk of bladder cancer.<\/p>\n

\n

The statement is based on the FDA’s review of data from a planned five-year interim analysis of an ongoing, ten-year epidemiological study, described in FDA’s September 2010 ongoing safety review<\/a>. The five-year results showed that although there was no overall increased risk of bladder cancer with pioglitazone use, an increased risk of bladder cancer was noted among patients with the longest exposure to pioglitazone, and in those exposed to the highest cumulative dose of pioglitazone.<\/p>\n<\/div>\n

The FDA is also aware of a recent epidemiological study conducted in France<\/a> which suggests an increased risk of bladder cancer with pioglitazone. Based on the results of this study, France has suspended the use of pioglitazone and Germany has recommended not to start pioglitazone in new patients.<\/p>\n

\n

The FDA recommends that healthcare professionals not use pioglitazone in patients with active bladder cancer and use pioglitazone with caution in patients with a prior history of bladder cancer. The benefits of blood sugar control with pioglitazone should be weighed against the unknown risks for cancer recurrence.<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

The U.S. Food and Drug Administration (FDA) issued a safety announcement informing the public that use of the type 2 diabetes medication Actos (pioglitazone) for more than one year may be associated with an increased risk of bladder cancer. Information about this risk will be added to the Warnings and Precautions section of the label for pioglitazone-containing medicines. The patient Medication Guide for these medicines…<\/p>\n","protected":false},"author":131,"featured_media":17120,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"","_relevanssi_noindex_reason":"","footnotes":""},"categories":[1442],"tags":[276,135],"yoast_head":"\nLong Term Use of Diabetes Drug Actos May Increase Risk of Cancer<\/title>\n<meta name=\"description\" content=\"The U.S. FDA issued a safety announcement that use of the type 2 diabetes medication Actos (pioglitazone) for more than one year may be associated with an increased risk of bladder cancer.\" \/>\n<meta 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