{"id":20960,"date":"2011-10-20T05:13:10","date_gmt":"2011-10-20T09:13:10","guid":{"rendered":"http:\/\/asweetlife.org\/?p=20960"},"modified":"2015-12-28T07:37:22","modified_gmt":"2015-12-28T12:37:22","slug":"fda-approves-byetta-for-use-with-lantus-insulin-in-the-u-s","status":"publish","type":"post","link":"https:\/\/asweetlife.org\/?p=20960","title":{"rendered":"FDA Approves Byetta for Use with Lantus Insulin in the U.S."},"content":{"rendered":"<div style=\"text-align: justify;\"><a href=\"https:\/\/asweetlife.org\/wp-content\/uploads\/2011\/10\/Amylin-Lilly-Logo-1.png\" rel=\"mfp\"><img decoding=\"async\" class=\"alignleft size-full wp-image-20962 lazyload\" title=\"Amylin Lilly Logo\" src=\"data:image\/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==\" data-src=\"https:\/\/asweetlife.org\/wp-content\/uploads\/2011\/10\/Amylin-Lilly-Logo-1.png\" alt=\"\" width=\"150\" height=\"44\" \/><\/a>The U.S. Food and Drug Administration (FDA) has approved a new use for\u00a0Amylin and Eli Lilly&#8217;s type 2 diabetes drug,\u00a0Byetta\u00a0(exenatide) injection.\u00a0 Byetta is now approved as an add-on therapy to insulin glargine (Lantus), with or without metformin and\/or a thiazolidinedione (TZD), for adults with type 2 diabetes who are not achieving adequate glycemic control on insulin glargine alone. The FDA approved Byetta as an add-on therapy to Lantus following a clinical trial where\u00a0patients using\u00a0Byetta\u00a0with insulin glargine achieved better glycemic control, without weight gain or an increased risk of hypoglycemia, compared to patients using Lantus alone.<\/div>\n<div style=\"text-align: justify;\">\u00a0<\/div>\n<div style=\"text-align: justify;\">In the study supporting the expanded use, patients receiving Lantus, with or without metformin and\/or a TZD, were randomized to receive\u00a0Byetta\u00a0or placebo in addition to aggressive insulin titration. After 30 weeks of treatment, A1c, a measure of average blood sugar over three months, decreased by 1.7 percentage points in patients adding\u00a0Byetta, compared with a decrease of 1.0 percentage point in patients treated with Lantus alone (p&lt;0.001). Nausea, which was the most common adverse event, occurred in 41 percent of patients treated with\u00a0Byetta\u00a0compared with 8 percent of patients treated with Lantus alone.\u00a0 On average, weight decreased by 4 pounds in patients adding\u00a0Byetta, compared with an increase of 2 pounds in patients treated with Lantus alone (p&lt;0.001). The greater improvement in A1c with\u00a0Byetta\u00a0was not accompanied by an increase in hypoglycemia, compared to Lantus alone.<\/div>\n<div style=\"text-align: justify;\">\u00a0<\/div>\n<div style=\"text-align: justify;\">The double-blind clinical trial evaluating\u00a0Byetta\u00a0as an add-on therapy to Lantus was published in Annals of Internal Medicine<\/div>\n<div>\n<div style=\"text-align: justify;\">\u00a0<\/div>\n<div style=\"text-align: justify;\">Byetta\u00a0was approved in the U.S. in April 2005 and in Europe in November 2006 and has been used by more than 1.8 million patients since its introduction.<\/div>\n<div style=\"text-align: justify;\">\u00a0<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>The U.S. Food and Drug Administration (FDA) has approved a new use for Amylin and Eli Lilly&#8217;s type 2 diabetes drug, Byetta (exenatide) injection.  Byetta is now approved as an add-on therapy to insulin glargine (Lantus), with or without metformin and\/or a thiazolidinedione (TZD), for adults with type 2 diabetes&#8230;<\/p>\n","protected":false},"author":131,"featured_media":29371,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"","_relevanssi_noindex_reason":"","footnotes":""},"categories":[1443,1441],"tags":[277,135,143],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v22.9 (Yoast SEO v22.9) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>FDA Approves Byetta for Use with Lantus Insulin in the U.S.<\/title>\n<meta name=\"description\" content=\"The FDA has approved a new use for Amylin and Eli Lilly&#039;s type 2 diabetes drug, Byetta (exenatide). 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