{"id":25223,"date":"2012-02-27T08:21:18","date_gmt":"2012-02-27T13:21:18","guid":{"rendered":"http:\/\/asweetlife.org\/?p=25223"},"modified":"2015-12-30T04:37:30","modified_gmt":"2015-12-30T09:37:30","slug":"beta-cells-may-function-years-after-type-1-diabetes-diagnosis","status":"publish","type":"post","link":"https:\/\/asweetlife.org\/?p=25223","title":{"rendered":"Beta Cells May Function Years After Type 1 Diabetes Diagnosis"},"content":{"rendered":"<div style=\"text-align: justify;\"><a href=\"https:\/\/asweetlife.org\/wp-content\/uploads\/2012\/02\/Mass-General-Hospital-logo.jpg\" rel=\"mfp\"><img decoding=\"async\" class=\"alignleft size-full wp-image-25225 lazyload\" title=\"Mass General Hospital - logo\" src=\"data:image\/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==\" data-src=\"https:\/\/asweetlife.org\/wp-content\/uploads\/2012\/02\/Mass-General-Hospital-logo.jpg\" alt=\"\" width=\"200\" height=\"233\" \/><\/a>A study conducted at\u00a0Massachusetts General Hospital (MGH) has found that insulin production may persist for decades after the onset of type 1 diabetes. \u00a0<\/div>\n<div style=\"text-align: justify;\">\n<div>\n<div>\n<div>\u00a0<\/div>\n<\/div>\n<div>In the study, led by\u00a0Denise Faustman, MD, PhD, director of the MGH\u00a0Immunobiology Laboratory,\u00a0blood samples from 182 individuals with type 1 diabetes were evaluated using an ultra sensitive assay (22 times\u00a0more sensitive than standard assays)\u00a0for C-peptide, a marker of insulin secretion, to test for residual beta cell function. The study revealed that C-peptide production can persist for decades after disease onset and remains functionally responsive to blood sugar levels.\u00a0 Although C-peptide levels were lower among those who had longer duration of diabetes, the decrease over time was gradual and not abrupt as traditionally believed. \u00a0Even among patients with disease duration of 31 to 40 years, 10 percent still produced C-peptide. \u00a0<\/div>\n<\/div>\n<div>\u00a0<\/div>\n<div>\n<p>These results contribute to a growing body of evidence suggesting there might be a longer window for therapeutic intervention in this disease. The assay offers a novel approach to identify patients, even with advanced disease, who upon glycemic stimulation may benefit from treatments to retain or enhance ?-cell function. Patients with low C-peptide levels or advanced disease should neither be uniformly excluded from clinical trials nor seen as having complete islet cell destruction.<\/p>\n<p>&nbsp;<\/p>\n<p>The study results appear in the March issue of\u00a0<em><a href=\"http:\/\/care.diabetesjournals.org\/content\/35\/3\/465.full\" target=\"_blank\">Diabetes Care<\/a><\/em>.<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<\/div>\n<div style=\"text-align: justify;\">\u00a0<\/div>\n","protected":false},"excerpt":{"rendered":"<p>A study conducted at Massachusetts General Hospital (MGH) has found that insulin production may persist for decades after the onset of type 1 diabetes.<br \/>\nIn the study, led by Denise Faustman, MD, PhD, director of the MGH Immunobiology Laboratory, blood samples from 182 individuals with type 1 diabetes were evaluated<\/p>\n","protected":false},"author":131,"featured_media":29352,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"","_relevanssi_noindex_reason":"","footnotes":""},"categories":[1445],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v22.9 (Yoast SEO v22.9) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Beta Cells May Function Years After Type 1 Diabetes Diagnosis<\/title>\n<meta name=\"description\" content=\"A study conducted at Massachusetts General Hospital has found that insulin production may persist for decades after 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