{"id":25487,"date":"2012-03-12T09:33:05","date_gmt":"2012-03-12T13:33:05","guid":{"rendered":"http:\/\/asweetlife.org\/?p=25487"},"modified":"2015-12-30T04:39:10","modified_gmt":"2015-12-30T09:39:10","slug":"gut-cells-of-mice-transformed-into-insulin-producers","status":"publish","type":"post","link":"https:\/\/asweetlife.org\/?p=25487","title":{"rendered":"Gut Cells of Mice Transformed into Insulin-Producers"},"content":{"rendered":"<p>The goal of a therapy for type 1 diabetes is restoration of regulated insulin secretion.\u00a0 A newly published <a href=\"http:\/\/www.nature.com\/ng\/journal\/vaop\/ncurrent\/full\/ng.2215.html\" target=\"_blank\">study<\/a>, conducted by Chutima Talchai, PhD, and Domenico Accili, MD, professor of medicine at Columbia University Medical Center, found insulin secretion in unexpected place &#8211; the gut.\u00a0 The researchers discovered that certain progenitor cells in the intestine of mice have the\u00a0 ability to make insulin-producing cells.\u00a0 When the researchers turned off a certain gene &#8212; Foxo1 &#8212; the progenitor cells also generated insulin-producing cells.\u00a0 According to a<a href=\"http:\/\/www.sciencedaily.com\/releases\/2012\/03\/120311150719.htm\" target=\"_blank\"> report <\/a>in ScienceDaily, &#8221; The insulin made by the gut cells also was released into the bloodstream, worked as well as normal insulin, and was made in sufficient quantity to nearly normalize blood glucose levels in otherwise diabetic mice.&#8221;<\/p>\n<p>For the press release see <a href=\"http:\/\/www.cumc.columbia.edu\/news-room\/2012\/03\/new-approach-to-treating-type-i-diabetes\/\" target=\"_blank\">here<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The goal of a therapy for type 1 diabetes is restoration of regulated insulin secretion.  A newly published study, conducted by Chutima Talchai, PhD, and Domenico Accili, MD, professor of medicine at Columbia University Medical Center&#8230;<\/p>\n","protected":false},"author":131,"featured_media":29346,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"","_relevanssi_noindex_reason":"","footnotes":""},"categories":[1445],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v22.9 (Yoast SEO v22.9) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Gut Cells of Mice Transformed into Insulin-Producers<\/title>\n<meta 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