{"id":5086,"date":"2010-02-20T12:12:18","date_gmt":"2010-02-20T17:12:18","guid":{"rendered":"http:\/\/asweetlife.org\/?p=5086"},"modified":"2015-12-27T15:44:30","modified_gmt":"2015-12-27T20:44:30","slug":"rebooting-the-body-anti-cd3-in-popular-science","status":"publish","type":"post","link":"https:\/\/asweetlife.org\/?p=5086","title":{"rendered":"Rebooting the Body: Anti-CD3 in Popular Science"},"content":{"rendered":"

I just had a feature published in Popular Science<\/a> that I think might be of interest to others with Type 1. As I’ve mentioned previously on this blog, right after being diagnosed with Type 1 diabetes 9 years ago, I enrolled in a trial for a new drug called an anti-CD3 monoclonal antibody (best known as teplizumab<\/a> and being studied in a trial called Protege<\/a> that is currently recruiting recently diagnosed diabetics to participate). The drug’s goal: to “reprogram” my immune system into not killing off insulin-producing cells, thus prolonging the honeymoon period and likely making \u00a0blood sugars easier to control. The result of my experience? I got the drug nearly a decade ago and I’m still making a measurable — if marginal — amount of insulin. I’m by no means cured, but damn, am I grateful to have given the drug a try.<\/p>\n

For all my positive experience with the trial, though, I’ll admit that I never got much beyond learning how to pronounce “anti-CD3 monoclonal antibody” (try saying that three times fast). What is it? How do researchers think it might work? What effects might it have on auto-immune diseases beyond just Type 1 diabetes?<\/p>\n

I recently got the chance not just to learn about this myself, but to write about it for Popular Science — and the result, a feature called “Rebooting the Body,” is in this month’s (March’s) issue, on newsstands now. Here’s a link to a digital copy<\/a> (a revised one, which should work)\u00a0— though please consider picking up a hard copy to support them for running it!\u00a0I wanted to give a heads-up that it might be of interest not just to people who have been recently diagnosed (if you have, you should definitely look up the ongoing trials) but to anyone with a family history of Type 1: Kevan Herold at Yale is heading a new round of trials<\/a> to see if the drug might be actually able to *prevent* Type 1 in people who have a high risk of getting it. There are tests available to get a sense of your chances.<\/p>\n

And also: as you may already know, one of the main issues in transplanting insulin-producing cells — whether they be from stem cells, pig cells, flowers<\/a>, or anything else — is figuring out how to prevent the same part of your immune system that caused Type 1 in the first place from killing off those cells again. Anti-CD3 monoclonal antibodies might be a solution to this problem — if you combine a new source of insulin-producing cells with a means to protect them, well, you’re getting yourself closer to a cure.<\/p>\n

Anyway, if you have access to a paper copy, check it out — if not, I’ll try to post a digital version here.<\/p>\n

On a less inspirational note: this morning, I dropped my pump into the toilet.<\/p>\n","protected":false},"excerpt":{"rendered":"

…<\/p>\n","protected":false},"author":9,"featured_media":53098,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"","_relevanssi_noindex_reason":"","footnotes":""},"categories":[1501],"tags":[],"yoast_head":"\nAnti-CD3 Monoclonal Antibodies in Popular Science<\/title>\n<meta name=\"description\" content=\"I just had an article published about Type 1 diabetes and a type of immune-modulating drug called an anti-CD3 monoclonal antibody (best known these days as teplizumab). 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