{"id":790,"date":"2009-09-18T01:04:39","date_gmt":"2009-09-18T01:04:39","guid":{"rendered":"http:\/\/asweetlife.org\/?p=790"},"modified":"2015-12-27T15:48:07","modified_gmt":"2015-12-27T20:48:07","slug":"mixed-meal-tolerance-test","status":"publish","type":"post","link":"https:\/\/asweetlife.org\/?p=790","title":{"rendered":"Mixed Meal Tolerance Test"},"content":{"rendered":"

So, I just got back from a trip home to the east coast to see my family, and decided that while I was at it, I should try to visit my old endocrinologist, Kevan Herold, who’s currently at Yale. Right after I was diagnosed I was lucky enough to be a participant in a study Dr. Herold was helping conduct on an anti-cd3 antibody that ended up being big news in the diabetes research community — by using an antibody against my own antibodies, the drug helped “reprogram” my immune system so that I stopped killing off my insulin-producing cells. (For more info on the study, click\u00a0here<\/a>.) Two years out, I was showing a slight \u00a0increase in insulin production compared to when I was diagnosed. Very exciting.<\/span><\/em><\/p>\n

It’s now been eight years since I found out I had diabetes, and Dr. Herold and his colleagues are conducting a follow-up study \u00a0to see how long the effects of the drug lasted. In other words, they had me come in and do some blood tests to see how much insulin I am or am not still \u00a0producing.<\/p>\n

In a practical sense, this meant spending the morning in the hospital doing a mixed meal tolerance test — you drink a sugary drink and then have your blood drawn about 11 times over the course of the next 5 hours to see how much insulin your body is able to produce. The results of the follow-up aren’t in yet, but participating in the trial re-inspired me to find out more about what’s going on in diabetic research.<\/p>\n

One particularly exciting study which others might find interesting is the possibility of using this particular drug as a potential vaccine for Type 1 diabetes. Herold and his colleagues are looking at people who have both a family member with diabetes and test positive for several diabetes-related antibodies (and who are below a certain age — I can’t remember what exactly) — risk factors which, when all present, have been found to have a 90 percent prediction rate for whether or not you’ll get Type 1. If the study works, it’ll be the closest we’ll have come to a vaccine for the disease. Pretty exciting stuff.<\/p>\n","protected":false},"excerpt":{"rendered":"

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