{"id":8903,"date":"2010-07-09T11:08:00","date_gmt":"2010-07-09T15:08:00","guid":{"rendered":"http:\/\/asweetlife.org\/?p=8903"},"modified":"2015-12-27T15:48:04","modified_gmt":"2015-12-27T20:48:04","slug":"8903","status":"publish","type":"post","link":"https:\/\/asweetlife.org\/?p=8903","title":{"rendered":"Hot off the press: the CANOE trial"},"content":{"rendered":"<p style=\"text-align: justify\">Despite the popularity of \u201chow to\u201d books on transforming our lives we Americans really do not like life-style change. This is one reason there has been such hesitancy in setting up to screen large numbers of people for insulin resistance \u2013 the first sign of insipient type 2 diabetes. Previous trials in which pre-diabetic people have been identified have failed to stop their march into that state of full blown diabetes \u2013 underscoring the incredible difficulty in real life style change.<\/p>\n<p style=\"text-align: justify\">We do like to take pills, however. This may explain the success of the most recent clinical trial in which 207 pre-diabetic patients were given either placebo or else a low-dose combination of rosiglitazone and metformin. The double blind trial was funded by GlaxoSmithKline and just reported today in the Lancet by Dr<strong>.<\/strong> Bernard Zinman and colleagues. The patients were followed for almost 4 years. Forty one patients (39.4%) in the placebo group developed diabetes. Fourteen patients (13.6%) in the treatment group developed diabetes. A great many metabolic variables were examined and nothing really changed (at least that I picked up on). Weight was unchanged as well. No serious side effects were reported.<\/p>\n<p><strong> <\/strong><\/p>\n<p style=\"text-align: justify\">So it looks like we have a winner. My only question is how they got the acronym \u201cCANOE\u201d from rosiglitazone, metformin, and prediabetes. Perhaps some things should remain a mystery.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>&hellip;<\/p>\n","protected":false},"author":26,"featured_media":53098,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"","_relevanssi_noindex_reason":"","footnotes":""},"categories":[1501],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v22.9 (Yoast SEO v22.9) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Finally: a treatment for prediabetes<\/title>\n<meta name=\"description\" content=\"Low dose rosiglitazone plus metformin has just been reported to decrease the onset of diabetes in a population with impaired glucose tolerance\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/asweetlife.org\/?p=8903\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Robert Scheinman\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/asweetlife.org\/?p=8903\",\"url\":\"https:\/\/asweetlife.org\/?p=8903\",\"name\":\"Finally: a treatment for prediabetes\",\"isPartOf\":{\"@id\":\"https:\/\/asweetlife.org\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/asweetlife.org\/?p=8903#primaryimage\"},\"image\":{\"@id\":\"https:\/\/asweetlife.org\/?p=8903#primaryimage\"},\"thumbnailUrl\":\"https:\/\/asweetlife.org\/wp-content\/uploads\/2021\/01\/ASL-Social-Big-Square-3.jpg\",\"datePublished\":\"2010-07-09T15:08:00+00:00\",\"dateModified\":\"2015-12-27T20:48:04+00:00\",\"author\":{\"@id\":\"https:\/\/asweetlife.org\/#\/schema\/person\/1857a46a471611e37da149a9f5904e39\"},\"description\":\"Low dose rosiglitazone plus metformin has just been reported to decrease the onset of diabetes in a population with impaired glucose tolerance\",\"breadcrumb\":{\"@id\":\"https:\/\/asweetlife.org\/?p=8903#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/asweetlife.org\/?p=8903\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/asweetlife.org\/?p=8903#primaryimage\",\"url\":\"https:\/\/asweetlife.org\/wp-content\/uploads\/2021\/01\/ASL-Social-Big-Square-3.jpg\",\"contentUrl\":\"https:\/\/asweetlife.org\/wp-content\/uploads\/2021\/01\/ASL-Social-Big-Square-3.jpg\",\"width\":1280,\"height\":1280},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/asweetlife.org\/?p=8903#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/asweetlife.org\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Hot off the press: the CANOE trial\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/asweetlife.org\/#website\",\"url\":\"https:\/\/asweetlife.org\/\",\"name\":\"ASweetLife\",\"description\":\"The Diabetes Magazine\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/asweetlife.org\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/asweetlife.org\/#\/schema\/person\/1857a46a471611e37da149a9f5904e39\",\"name\":\"Robert Scheinman\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/asweetlife.org\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/b79d3258e275356dc9bd3937dc6b6920?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/b79d3258e275356dc9bd3937dc6b6920?s=96&d=mm&r=g\",\"caption\":\"Robert Scheinman\"},\"description\":\"Robert Scheinman received a PhD in Pharmacology in 1990 and joined the faculty of the University of Colorado Denver School of Pharmacy in 1995. 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