Obesity is the main culprit in the worldwide avalanche of type 2 diabetes. But how excess weight drives insulin resistance, the condition that may lead to the disease, is only partly understood. Scientists at Joslin Diabetes Center now have uncovered a new way in which obesity wreaks its havoc, by altering the production of proteins that affect how other proteins are spliced together. Their finding, published in Cell Metabolism, may point toward novel targets for diabetes drugs...
Category: Science
Currently, beta-cell death is very hard to measure...
XOMA announced the first presentation of results from its discovery of two new classes of fully human monoclonal antibodies that activate or sensitize the insulin receptor in vivo, each representing a distinct new therapeutic approach to the treatment of patients with diabetes. The data were presented at the American Diabetes Association 71st Scientific Sessions in San Diego...
Diamyd Medical has suspended dosing in its US Phase III study, DiaPrevent, with the antigen-based therapy Diamyd® following consultation with the US Food and Drug Administration (FDA). Termination follows a blinded review of the efficacy data collected to date in the study as well as the previously reported negative outcome...
Harrison and his team have pushed forward with a trial of the nasal insulin vaccine believing they are on the path to prevent the autoimmune destruction of beta cells...
The bio artificial pancreas is implanted subcutaneously and oxygen is delivered to the islets via injection...
Researchers at Joslin Diabetes Center have identified an enzyme called PKC-delta as an important molecular modifier for development of insulin resistance, diabetes and fatty liver in mice. They also have found evidence suggesting a similar role for the enzyme in humans...
The first day off insulin I ate a ham sandwich. My blood sugar didn’t go up. Now I knew how regular people felt after they ate a sandwich. I considered it a miracle...
Global sports organization Team Type 1, the official parent company of the Team Type 1- sanofi aventis professional men’s cycling team, announced the launch a clinical study at the Amgen Tour of California. The pioneering study conducted by the Team Type 1 Diabetes Sports Research Institute, will assess blood glucose levels of elite cyclists...
Researchers from UCLA's Larry L. Hillblom Islet Research Center have discovered the underlying mechanism that could convert other cell types into pancreatic beta cells.
It had long been assumed that the identity of cells was "locked" into place and that they could not be switched into other cell types...