Category: Research

Faustman Lab Research: How Excited Should You Be?

Last week, diabetes headlines were dominated by a new study from the Faustman Lab at Massachusetts General Hospital, published on Wednesday, August 8th on PLoS One, suggesting that a 90-year-old tuberculosis vaccine called BCG might hold promise for people living with type 1 diabetes. “Human Study Reignites Debate Over Controversial Diabetes ‘Cure,’” wrote Reuters. “Diabetes May Be Reversed By Long-Used Vaccine for TB,” proclaimed Bloomberg news.
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Treatment With Generic Vaccine May Temporarily Reverse Type 1 Diabetes

A phase I clinical trial, led by Denise Faustman, MD, PhD, director of the Massachusetts General Hospital (MGH) Immunobiology Laboratory, has confirmed that use of a generic vaccine to raise levels of an immune system modulator can cause the death of autoimmune cells targeting the insulin-secreting cells of the pancreas and temporarily restore insulin secretion in human patients with type 1 diabetes.
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Immunomodulators for Treatment of Type 1 Diabetes: An Overview

In the 1980s, studies demonstrated that suppressing the immune system of people recently diagnosed with T1D reduced their insulin dependence and provided persuasive evidence that T1D is an autoimmune disease. “Back then it wasn't so clear,” says immunologist Jeffrey Bluestone of the University of California, San Francisco.
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Cebix Presents C-peptide Replacement Therapy Data

Cebix Incorporated today announced that data from a Phase 1 study demonstrated that Ersatta(TM), the company's long-acting form of C-peptide, was well tolerated with no serious adverse events in patients with type 1 diabetes and exhibited...
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DiaPep277 Granted Orphan Drug Designation by FDA

The U.S. FDA has granted Orphan Drug designation for DiaPep277 for the treatment of type 1 diabetes (T1D) patients with residual beta cell function. The designation of Orphan Drug status offers 7 years marketing exclusivity from the time of approval....
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Proving the Hygiene Hypothesis?

Proving the Hygiene Hypothesis?

The hygiene hypothesis sounds plausible, especially in light of studies that have found increasing rates of diseases like type 1 diabetes in developed and developing countries...
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Researchers Find Possible Trigger in Development of Type 1 Diabetes

JDRF-funded scientists from the Indiana University School of Medicine have found that a specific type of cellular stress takes place in pancreatic beta cells before the onset of type 1 diabetes and this stress response in the beta cell may in fact help ignite the autoimmune attack....
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