NIH has launched a long-term clinical trial called the GRADE study. Researchers will examine the benefits and risks of common diabetes drugs used with metformin. Metformin is often the first line of treatment in type 2 diabetes. If metformin isn’t enough to keep blood glucose in check, doctors sometimes add another drug. But no long-term studies have looked at which drug combination works best and has fewer side effects.
To address this issue, Scientists hope to enroll about 5,000 participants at 37 locations across the country. All volunteers will take metformin, along with a second medication randomly assigned from among 4 classes of drugs approved for use with metformin by the U.S. Food and Drug Administration.
Participants will have their diabetes medications managed free of charge during the study. Other health care must come from participants’ own providers.
Learn more about the GRADE study at http://grade.bsc.gwu.edu