Researchers Create Smart Insulin that Reacts to Glucose Levels

Smart Insulin

Researchers at MIT successfully tested an engineered “smart insulin” on mice that reacts to blood sugar levels. “To make insulin that is glucose responsive is something that we believe will significantly improve blood sugar control in people with diabetes,” said … Read more

Building Beta Cells: An Interview with Dr. Timothy Kieffer

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Timothy Kieffer - Lab

The benefit of making mature beta cells entirely in the dish is that they may be a useful resource for research aimed at understanding the causes of diabetes (both Type 1 and Type 2) as well as developing new therapeutic strategies for diabetes. Moreover, ultimately, mature beta cells may prove to be better than pancreatic progenitor cells for transplant into patients with diabetes. Read more

Survey Shows Hispanics Lack Important Information About Diabetes

Survey Shows Hispanics Lack Important Information About Diabetes

A new survey reveals that many Hispanics are aware that diabetes is dangerous, but compared to non-Hispanics, they are poorly informed about how to best treat the disease. The survey may reveal ways to enact more effective communication tools to better inform Hispanics about improving their diabetes care.
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Orgenesis Receives New Patent for Potential T1D Cure

Orgenesis - cartoon by Jennefir Jacobs

The liver and pancreas originate from the same embryonic lineage – the endoderm. In fact, both organs develop from the same original group of cells in the embryo. Because of this, they also share many genetic transcription factors and – perhaps most importantly – they each have a built-in glucose sensing system. Read more

On the Road to a Type 1 Diabetes Cure: Melton Lab Creates Functioning Beta Cells

Human stem cell derived beta cells

Using human embryonic stem cells as a base, the lab has pioneered a process that can reproduce human, insulin-producing beta cells on a large scale. As Melton said in a conference call with journalists, “What we’re reporting on is something that I think was obvious to many as a possible solution but just turned out to be difficult to achieve, and that is the creation of human beta cells that properly respond to sugar or glucose and secrete the right amount of insulin.” Read more

Can Treg Infusions Thwart the Immune Response in Type 1 Diabetes?

Treg Infusains

What researchers are investigating through Rooney’s trial is whether or not another component of the immune system called T regulatory cells, or Tregs, can thwart the aggressive immune response that destroys beta cells, according to Dr. Douglas Losordo, Chief Medical Officer for NeoStem, the company developing and testing the Treg treatment. Read more

Islet Cell Transplant for Type 2 Diabetes: Could it Work?

Human Islet - Dr. Gordon Weir - Home

“I’m a big proponent of islet cell transplantation for type 2 diabetics,” says Dr. Gordon Weir, who is one of the world’s foremost experts on islet cell transplantation as Co-Head of the Section on Islet Cell and Regenerative Biology, the Diabetes Research and Wellness Foundation Chair at the Joslin Diabetes Center, and Professor of Medicine at Harvard Medical School. “I tell people this and they look at me like I’m a little nuts. But, I believe there is no reason it couldn’t work effectively. I’m actually more optimistic about islet cell transplant for type 2 than for type 1.” Read more

Azurite: Attempting to Develop a Noninvasive Continuous Glucose Monitor

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Azurite -

Azurite’s idea is based on the fact that an electromagnetic signal, depending on its wavelength, can bounce off a surface and return to its source with a particular pattern reflective of the surface it encountered. Glucose molecules, like any material, reflect a unique electromagnetic signal based on their inherent electrical properties. So Azurite hopes to bounce an electromagnetic signal off the glucose in your blood, Read more

Lawrence Steinman’s ‘Reverse Vaccine’ Targets Immune Response in Type 1 Diabetes

Reverse Vaccine - Lawrence Steinman

Sometimes, when you’re stuck and spinning your wheels without making much forward progress, putting it in reverse can get you going. That’s what Dr. Lawrence Steinman and his colleagues are doing by attempting to cure type 1 diabetes with a unique and groundbreaking “reverse vaccine.”
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Diabetes Cure Research: Turning Duct Cells into Beta Cells

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Picture of Pancreas

Bonner-Weir and other scientists have argued that either the beta cells in the pancreas continue to make copies of themselves, or that the pancreatic ducts, through a process called budding or neurogenesis, continue producing new cells. Read more

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