Islet Cell Transplant for Type 2 Diabetes: Could it Work?

Human Islet - Dr. Gordon Weir - Home

“I’m a big proponent of islet cell transplantation for type 2 diabetics,” says Dr. Gordon Weir, who is one of the world’s foremost experts on islet cell transplantation as Co-Head of the Section on Islet Cell and Regenerative Biology, the Diabetes Research and Wellness Foundation Chair at the Joslin Diabetes Center, and Professor of Medicine at Harvard Medical School. “I tell people this and they look at me like I’m a little nuts. But, I believe there is no reason it couldn’t work effectively. I’m actually more optimistic about islet cell transplant for type 2 than for type 1.” Read more

Azurite: Attempting to Develop a Noninvasive Continuous Glucose Monitor

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Azurite -

Azurite’s idea is based on the fact that an electromagnetic signal, depending on its wavelength, can bounce off a surface and return to its source with a particular pattern reflective of the surface it encountered. Glucose molecules, like any material, reflect a unique electromagnetic signal based on their inherent electrical properties. So Azurite hopes to bounce an electromagnetic signal off the glucose in your blood, Read more

Lawrence Steinman’s ‘Reverse Vaccine’ Targets Immune Response in Type 1 Diabetes

Reverse Vaccine - Lawrence Steinman

Sometimes, when you’re stuck and spinning your wheels without making much forward progress, putting it in reverse can get you going. That’s what Dr. Lawrence Steinman and his colleagues are doing by attempting to cure type 1 diabetes with a unique and groundbreaking “reverse vaccine.”
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Diabetes Cure Research: Turning Duct Cells into Beta Cells

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Picture of Pancreas

Bonner-Weir and other scientists have argued that either the beta cells in the pancreas continue to make copies of themselves, or that the pancreatic ducts, through a process called budding or neurogenesis, continue producing new cells. Read more

Ways to Avoid Diabetes Complications: Talking to Joslin’s Dr. George L. King

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Gold Medals

King’s research into understanding the causes of diabetes complications, so he can help to find ways of preventing them through treatments and lifestyle changes, extends far beyond the confines of a lab or a petri dish. He is working with more than 800 people in the Joslin Diabetes Medalist program Read more

The Orgenesis Approach to a Diabetes Cure: Turning Liver Cells into Beta Cells

Orgenesis process - Home

Dr. Ferber wants to take a patient’s own liver cells, turn them into beta cells in the lab, and then put them back in the patient just like an islet cell transplant. Because the starting cells are the patient’s own cells, important protein markers on the cells would “match” what the patient’s immune system expects, and the cells would in theory not induce an immune reaction like an organ transplant would. Read more

Why Everyone is Talking About Glucagon

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Glucagon

In anticipation of stable, liquid glucagon, one of the newest entrants into the insulin pump space, Tandem Diabetes Care has jumped ahead of the crowd and created a two-chamber infusion pump capable of holding and injecting both insulin and a secondary hormone, which they expect will be glucagon. This tandem Tandem pump is already being tested in Dr. Ed Damiano’s clinical trial of a dual-hormone bionic pancreas. Read more

Cure for Type 1 Diabetes and MS? Discovery of Immune Suppressing Protein CD52

T-cell Regulation home

Dr. Harrison and his team identified that some T cells express a molecule on their surfaces, CD52, that is capable of suppressing other T cells. Understanding the ways in which the immune system normally controls and suppresses T cells is crucial to our understanding what goes wrong in autoimmune diseases. Read more

Islet Cell Transplant Progress May Lead to Type 1 Diabetes Cure

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The biomaterial holding the islet cells—which is completely synthetic, is 96 percent water, and which Garcia described as having the consistency of diluted Jello-O—and that was infused into the mice, however, addresses several of these problems. Read more

Dee and Bill Brehm: Working Toward a Type 1 Diabetes Cure

Dee and Bill Drehm 1

One Sunday evening in 1999, as Dee was preparing dinner, Bill entered their kitchen and asked if he could do anything to help her. Dee turned quickly and said defiantly, “You can cure this disease.” Bill was quiet for a moment, and then said, “OK”. So that began their serious quest for a Type 1 diabetes cure and Type 1 diabetes prevention. Read more

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