Lawrence Steinman’s ‘Reverse Vaccine’ Targets Immune Response in Type 1 Diabetes

Reverse Vaccine - Lawrence Steinman

Sometimes, when you’re stuck and spinning your wheels without making much forward progress, putting it in reverse can get you going. That’s what Dr. Lawrence Steinman and his colleagues are doing by attempting to cure type 1 diabetes with a unique and groundbreaking “reverse vaccine.”
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Type 2 Diabetes Treatments May Benefit People with Type 1 Diabetes

Type 2 Diabetes Treatments May Benefit People with Type 1 Diabetes

The change in thinking about the ways type 2 diabetes evolves indirectly opened the door to considering new ways of thinking about how type 1 diabetes behaves. That shift led to considering whether that door swung both ways and if type 1 diabetics might benefit from treatments designed to treat type 2 diabetes.
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Databetes: A Data-Driven Approach to Diabetes Management

Databetes - Home

Doug Kanter is now building a company, Databetes, that aims to make this level of tracking and analysis more broadly accessible. In a Databetes world, we can all be data geeks with really excellent A1Cs. Read more

Diabetes Cure Research: Turning Duct Cells into Beta Cells

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Picture of Pancreas

Bonner-Weir and other scientists have argued that either the beta cells in the pancreas continue to make copies of themselves, or that the pancreatic ducts, through a process called budding or neurogenesis, continue producing new cells. Read more

Diabetes: The Ultimate Preparation for Turning 30

30th birthday  - H

I was diagnosed with type 1 diabetes when I was 12, so, by that calculation, by the time I was 14, I felt 29. That means, right now, if I’m 30 in regular years, I’m 149 in diabetes years (and I’m 210 in dog years, in case you were wondering). What an accomplishment! You might be wondering if I really feel like I’m 149.
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Who Cares About Type 1 Diabetes?

One-in-a-Million

We need to stop complaining about how many times mice have been cured of diabetes. That is part of science, and part of learning about each separate part of the complex puzzle that makes up diabetes. We should embrace the researchers who are interested in solving our problem. Read more

Insulin Overdose: How I Got Insurance to Cover my CGM

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Insulin Overdose- How I Got Insurance to Cover my CGM

I decided to take matters into my own hands and take advantage of the misguided system. I prepared myself to visit the ER with a blood glucose level under 50 mg/dL. In other words, I planned an insulin overdose. Read more

The Orgenesis Approach to a Diabetes Cure: Turning Liver Cells into Beta Cells

Orgenesis process - Home

Dr. Ferber wants to take a patient’s own liver cells, turn them into beta cells in the lab, and then put them back in the patient just like an islet cell transplant. Because the starting cells are the patient’s own cells, important protein markers on the cells would “match” what the patient’s immune system expects, and the cells would in theory not induce an immune reaction like an organ transplant would. Read more

How Long Can a Diabetes Honeymoon Last?

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Honeymoon

When our six-year-old daughter, Bisi, was hospitalized last summer after being diagnosed with type 1 diabetes, part of the torrent of information we learned is that some patients have a diabetes honeymoon period, where the pancreas starts working again—though not perfectly—after diagnosis. Read more

Cure for Type 1 Diabetes and MS? Discovery of Immune Suppressing Protein CD52

T-cell Regulation home

Dr. Harrison and his team identified that some T cells express a molecule on their surfaces, CD52, that is capable of suppressing other T cells. Understanding the ways in which the immune system normally controls and suppresses T cells is crucial to our understanding what goes wrong in autoimmune diseases. Read more

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