Research | Page 11 of 22

Dee and Bill Brehm: Working Toward a Type 1 Diabetes Cure

One Sunday evening in 1999, as Dee was preparing dinner, Bill entered their kitchen and asked if he could do anything to help her. Dee turned quickly and said defiantly, “You can cure this disease.” Bill was quiet for a moment, and then said, “OK”. So that began their serious quest for a Type 1 diabetes cure and Type 1 diabetes prevention.

Discovery of Betatrophin: A New Hope for Beta Cell Replication

Dr. Doug Melton's group at Harvard, which has made many advances in our understanding of stem cell and beta cell biology over the years, has identified a new hormone, which they called betatrophin, that, when produced by the liver, induces beta cell growth in the islets of the pancreas.

Does Sugar Cause Diabetes?

Does eating too much sugar cause diabetes? It’s not entirely clear, but a population-based study published February 27 in the peer-reviewed, online journal PLoS One identifies a relevant correlation.

Diamyd to Launch New Clinical Study of Diabetes Vaccine in Children

Diamyd Medical is planning to launch a new clinical study with its diabetes vaccine, Diamyd, during February 2013. The study, approved by the Swedish Medical Products Agency, combines the diabetes vaccine Diamyd with relatively high doses of vitamin D and the anti-inflammatory drug ibuprofen. The purpose of the treatment is to preserve the body's own ability to control the blood sugar level in children and adolescents newly diagnosed with type 1 diabetes.

Diabetes Research Breakthrough: How Insulin Binds

For more than 20 years scientists have been trying to solve the mystery of how insulin binds to the insulin receptor, a discovery which could help improve treatments for both patients with type 1 and type diabetes. It seems that a research team at the Walter and Eliza Hall Institute in Melbourne, Australia, led by Associate Professor Mike Lawrence, Dr Colin Ward and Dr John Menting have now found the answer.

What Triggers Type 2 Diabetes? New Research From UCSB

A group of biomedical researchers at UC Santa Barbara is studying the metabolism of cells and their surrounding tissue, to ferret out ways in which certain diseases begin. This approach, which includes computer modeling, can be applied to type 2 diabetes, autoimmune diseases, and neurodegenerative diseases, among others.

T1D Exchange and Sanofi Team Up For Study Of Diabetes Care in Young Patients

T1D Exchange, a non-profit organization focused on type 1 diabetes, and Sanofi have joined forces in the TEENs registry study, a study aimed at providing a better understanding of how children, adolescents and young adults are currently living with type 1 diabetes and to deliver recommendations for better disease management and patients outcomes.

Type 1 Diabetes TrialNet Prevention Study Open to Younger Children

Incidence of type 1 diabetes is increasing and the disease is presenting at earlier ages. Each year, in the U.S. alone, approximately 15,000 children and adolescents are diagnosed with type 1 diabetes. It is one of the most common chronic diseases in school-aged children.

An In-Depth Look at the Faustman Lab Research – Part 2

Faustman holds that BCG vaccination's primary role in this case is to induce TNF-a expression, and that TNF-a's primary role in this case is to kill the defective autoreactive T cells after they have developed, implying that treatment with BCG will only work with patients who are already diabetic. Faustman put her theory to the test and treated three long-term diabetics with BCG to see whether it would have any effect on their disease status.

TNF, BCG, and You and Me: An In-Depth Look at the Faustman Lab Research

And here’s where things get interesting for a cure-seeking diabetic: when scientists saw that cells were flooding islets with TNF-a, they decided to see what would happen if they changed the levels of TNF-a in mouse pancreases– and they found that changing the levels of TNF-a changes whether a mouse will get diabetes. Now take a guess: we have a blaring distress signal, TNF-a, that turns on all the cells of the adaptive immune system, and we have a disease that is characterized by adaptive immune cells overreacting and killing the body’s own cells...