Scientists have found that blood levels of some ribonucleic acids (microRNAs) are different among people with type 2 diabetes and those who subsequently develop the disease compared to healthy controls, according to research reported in Circulation Research: Journal of the American Heart Association.
“We think that some of these microRNA changes may precede the onset of diabetes,” said Manuel Mayr, M.D., Ph.D., corresponding author of the study. “Future studies will need to confirm whether these new markers can help to actually target therapies and assess patients.”
Previous studies have linked microRNAs to numerous diseases, including diabetes. MicroRNA comprises shorter molecular chains than so-called messenger RNA, which takes the genetic information contained within the DNA and allows it to be turned into proteins with various functions. While microRNAs don’t translate genetic information, they help regulate protein expression by binding to the longer messenger RNAs.
Although they’re found throughout the body, this investigation focused on microRNAs that circulate in the blood. The investigators analysed microRNAs in blood samples of the Bruneck study, a large population-based survey of heart and other major diseases, including diabetes. Initial blood-sample screens in 1995 yielded 13 microRNAs with distinct differences among diabetics compared to non-diabetics.
The scientists further analyzed these 13 microRNAs to identify the ones that showed the most variation between diabetics and healthy controls. Study participants underwent follow-up screening in 2000 and 2005. Of note, changes in five microRNAs occurred before the onset of Type 2 diabetes. The levels of one microRNA in particular, microRNA 126, which helps to form new blood vessels and regulates their maintenance, was measured in all participants of the Bruneck study and was among the most reliable predictors of current and subsequent diabetes.
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